Dr. Rosemarie Osborne provides us with a summary of her findings in the Multi-Decade Ethnicity study that focuses on skin aging among different ethnic groups at the Spring Dermatology Update 2016 in Toronto, Canada. Taking a Systems Biology approach, this study combines the macro with the micro–molecular biology and genetic analysis, with facial appearance and other visible markers of aging. This large scale study can help define what makes some people look younger or older than their actual age, how to be a part of the younger looking group, and how changes manifest in different ethnic groups.