Dermatology Update 2016


Montréal, Le Centre Sheraton - NOVEMBER 3-6, 2016

Skin Barrier Defects Associated with Atopic Dermatitis (AD) and Prolonging Flare-free Periods

Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease that affects both children and adults [1]. It is a condition that is associated with cutaneous hypersensitivity to potentially multiple environmental triggers, which can be attributed to skin barrier defects and immune dysregulations [2]. We look to explore the latest hypotheses regarding these abnormalities that contribute to AD [2]. This presentation will also examine the mechanisms of action for tacrolimus (Protopic 0.03% and 0.1%), a topical calcinuerin inhibitor for the management of AD, and its’ effects on the skin barrier. Tacrolimus has been shown to be effective in relieving the symptoms of AD, as well as prolonging flare-free periods in patients with AD. We will examine available clinical evidence for the use of tacrolimus in this regard and ongoing clinical trials in this area. This talk will also discuss potential adverse events associated with the use of tacrolimus and strategies to managing these outcomes in clinical practice.


Dr. Maha Dutil

Dr. Maha Dutil

Dermatologist, Toronto, ON


1. Lynde C, Barber K, Claveau J, et al. Canadian practical guide for the treatment and management of atopic dermatitis. J Cutan Med Surg. 2005;8 Suppl 5:1-9.
2. Cork MK, Robinson DA, Vasilopoulos Y, et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene–environment interactions. J Allergy Clin Immunol. 2006;118:3-21.