Dermatology Update 2016

SESSIONS & ABSTRACTS

Montréal, Le Centre Sheraton - NOVEMBER 3-6, 2016

What is new in the treatment of Urticaria?

Objectives and Description:

  • Discuss clinical challenges of treating urticaria (disease states and pathophysiology)
  • Review  treatment options (benefits of using antihistamines)
  • Discuss management of chronic urticaria with a new second generation antihistamine – Bilastine

Chronic urticaria has a wide spectrum of clinical presentations and causes and is characterized by itchy wheal and flare responses due to the release of histamine and other pro-inflammatory mediators.1  About 30-50% of patients with chronic idiopathic urticaria have circulating histamine releasing autoantibodies to the high-affinity IgE receptor FcɛRI on basophils and mast cells or, less commonly, antibodies to IgE.1,2 Despite best research efforts no cause may be found in the majority of cases. 1,2

The current treatment options are: Primary prevention in the form of avoidance of aggravating factors; counseling; non-sedating antihistamines; leukotriene receptor antagonists; prednisolone; sulfasalazine omalizumab and a host of immunosuppressives like methotrexate and cyclosporine.2   The first treatment choice is non-sedating H1-antihistamines, dosages of which may be increased up to fourfold if standard doses are ineffective.2,3   Clinical challenges of treating urticaria, the benefits of using new generation antihistamines such as bilastine and the supporting clinical evidence will be discussed.

Agenda:

14:45 – 14:50 Welcome and Introductions Dr. Charles Lynde
14:50 – 15:05 Challenges in Treating Urticaria:
Disease state, treatment options and challenges with current antihistamines in Canada
Dr. John Kraft
15:05 – 15:10 Questions & Answers  
15:10 – 15:45 Bilastine Clincal Data, my approach to CSU/itch and future updates to guidelines Dr. Frank Siebenhaar
15:45 – 15:55 Questions & Answers  
15:55 – 16:00 Conclusions and Closing Remarks Dr. Charles Lynde

Speakers

Dr. Charles Lynde

Dr. Charles Lynde

Dermatologist, Markham, ON, Canada

Dr. John Kraft

Dr. John Kraft

Dermatologist, Markham, Ontario

Dr. Frank Siebenhaar

Dr. Frank Siebenhaar

Allergologist, Berlin, Germany

References

  1. Godse KV. Autologous serum skin test in chronic idiopathic urticaria. Indian J Dermatol Venereol Leprol. 2004;70:283–4.
  2. Bernstein JA, Lang DM, Kahn DA, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol 2014;133:1270-7
  3. Krause K, Spohr A, Zuberbier T, et al. Up-dosing with bilastine results in improved effectiveness in cold contact urticaria. Allergy 2013 Jul;68(7):921-8.